Largest nonprofits in Iowa by revenue
| # | Nonprofit | City | Focus area | Revenue |
|---|---|---|---|---|
| 1 | Central Iowa Hospital Corporation | Des Moines | Health Care | $1.4 billion |
| 2 | Catholic Health Initiatives-Iowa Corp | Des Moines | Health Care | $1.0 billion |
| 3 | Mercy Health Services Iowa Corp | Sioux City | Health Care | $933.9 million |
| 4 | Genesis Health System | Davenport | Health Care | $736.1 million |
| 5 | Iowa Physicians Clinic Medical Foundation | Wdm | Health Care | $615.1 million |
| 6 | Mercy Medical Center | Cedar Rapids | Health Care | $524.5 million |
| 7 | St Lukes Methodist Hospital | Cedar Rapids | Health Care | $502.6 million |
| 8 | Southeast Iowa Regional Medical Center Inc | W Burlington | Health Care | $457.0 million |
| 9 | Allen Memorial Hospital Corporation | Waterloo | Health Care | $443.1 million |
| 10 | Iowa Health System | Wdm | Health Care | $442.4 million |
| 11 | Covenant Medical Center Inc | Waterloo | Health Care | $436.4 million |
| 12 | Lifespace Communities Inc | Wdm | Human Services | $391.2 million |
| 13 | The Trustees Of Grinnell College | Grinnell | Education | $361.9 million |
| 14 | Unitypoint At Home | Wdm | Not listed | $286.3 million |
| 15 | Care Initiatives | Wdm | Health Care | $271.9 million |
| 16 | Drake University | Des Moines | Education | $256.3 million |
| 17 | Northwest Iowa Hospital Corporation | Sioux City | Health Care | $254.3 million |
| 18 | St Ambrose University | Davenport | Education | $230.5 million |
| 19 | Trinity Regional Medical Center | Fort Dodge | Health Care | $206.0 million |
| 20 | State University Of Iowa Foundation | Iowa City | Education | $202.5 million |
| 21 | Iowa State University Foundation | Ames | Education | $196.2 million |
| 22 | University Of Dubuque | Dubuque | Education | $178.7 million |
| 23 | Jennie Edmundson Memorial Hospital | Council Blfs | Health Care | $172.2 million |
| 24 | The Finley Hospital | Dubuque | Health Care | $160.8 million |
| 25 | Community Fdn Of Greater Des Moines | Des Moines | Philanthropy, Voluntarism & Grantmaking Foundations | $160.8 million |
The full list includes all 1,078 Iowa nonprofits with $1M+ revenue, with street address, ZIP, EIN, assets, income and tax period, plus every other state.
Iowa cities with the most $1M+ nonprofits
- Des Moines: 148
- Cedar Rapids: 74
- Sioux City: 53
- Iowa City: 48
- Davenport: 43
- Dubuque: 42
- Waterloo: 33
- Ames: 32
- Wdm: 30
- Johnston: 25
Most common focus areas
- Human Services: 186
- Health Care: 137
- Education: 126
- Arts, Culture & Humanities: 53
- Housing & Shelter: 51
- Philanthropy, Voluntarism & Grantmaking Foundations: 46
- Mental Health & Crisis Intervention: 36
- Community Improvement & Capacity Building: 31
Where does this data come from?
The IRS Exempt Organizations Business Master File, downloaded in October 2026. Figures are as reported on each organization's latest return on file with the IRS. Personal contact names are not included.