Largest nonprofits in South Dakota by revenue
| # | Nonprofit | City | Focus area | Revenue |
|---|---|---|---|---|
| 1 | Sanford | Sioux Falls | Not listed | $6.1 billion |
| 2 | Avera McKennan | Sioux Falls | Health Care | $1.9 billion |
| 3 | Monument Health Rapid City Hospital Inc | Rapid City | Health Care | $1.1 billion |
| 4 | Signatry Charitable Trust | Sioux Falls | Philanthropy, Voluntarism & Grantmaking Foundations | $1.0 billion |
| 5 | The Evangelical Lutheran Good Samaritan Society | Sioux Falls | Human Services | $1.0 billion |
| 6 | Avera Health | Sioux Falls | Health Care | $359.1 million |
| 7 | Monument Health Network Inc | Rapid City | Health Care | $221.1 million |
| 8 | Sanford Health Foundation | Sioux Falls | Philanthropy, Voluntarism & Grantmaking Foundations | $214.4 million |
| 9 | Prairie Lakes Health Care System Inc | Watertown | Health Care | $202.9 million |
| 10 | Avera St Lukes | Aberdeen | Health Care | $194.4 million |
| 11 | Sacred Heart Health Services | Yankton | Health Care | $182.2 million |
| 12 | Avera Queen Of Peace | Mitchell | Health Care | $159.9 million |
| 13 | Great Plains Tribal Leaders Health Board | Rapid City | Mental Health & Crisis Intervention | $159.1 million |
| 14 | Augustana University Association | Sioux Falls | Education | $140.9 million |
| 15 | Avera St Marys | Pierre | Health Care | $133.9 million |
| 16 | Native American Heritage Association | Black Hawk | Crime & Legal-Related | $108.3 million |
| 17 | Avera At Home | Sioux Falls | Health Care | $88.2 million |
| 18 | South Dakota State University Foundation | Brookings | Education | $73.3 million |
| 19 | Childrens Care Hospital & School | Sioux Falls | Not listed | $73.2 million |
| 20 | Rural Health Care Inc | Fort Pierre | Not listed | $68.9 million |
| 21 | South Dakota Community Foundation | Pierre | Philanthropy, Voluntarism & Grantmaking Foundations | $60.1 million |
| 22 | Huron Regional Medical Center Inc | Huron | Health Care | $57.2 million |
| 23 | Sioux Falls Area Community Foundation Inc | Sioux Falls | Philanthropy, Voluntarism & Grantmaking Foundations | $50.6 million |
| 24 | Black Hills Works Inc | Rapid City | Employment | $50.1 million |
| 25 | South Dakota Achieve | Sioux Falls | Human Services | $46.6 million |
The full list includes all 380 South Dakota nonprofits with $1M+ revenue, with street address, ZIP, EIN, assets, income and tax period, plus every other state.
South Dakota cities with the most $1M+ nonprofits
- Sioux Falls: 109
- Rapid City: 50
- Pierre: 21
- Brookings: 16
- Aberdeen: 14
- Mitchell: 12
- Watertown: 10
- Huron: 9
- Madison: 8
- Spearfish: 8
Most common focus areas
- Health Care: 58
- Human Services: 57
- Education: 40
- Community Improvement & Capacity Building: 24
- Arts, Culture & Humanities: 18
- Mental Health & Crisis Intervention: 15
- Philanthropy, Voluntarism & Grantmaking Foundations: 12
- Housing & Shelter: 12
Where does this data come from?
The IRS Exempt Organizations Business Master File, downloaded in October 2026. Figures are as reported on each organization's latest return on file with the IRS. Personal contact names are not included.