Largest nonprofits in North Carolina by revenue
| # | Nonprofit | City | Focus area | Revenue |
|---|---|---|---|---|
| 1 | Novant Health Inc | Winston Salem | Health Care | $6.5 billion |
| 2 | Duke University Health System Inc | Durham | Health Care | $6.2 billion |
| 3 | Duke University | Durham | Education | $4.8 billion |
| 4 | North Carolina Baptist Hospital | Winstonsalem | Health Care | $3.3 billion |
| 5 | Gothic Corporation | Durham | Education | $3.2 billion |
| 6 | Wakemed | Raleigh | Health Care | $2.6 billion |
| 7 | Presbyterian Hospital | Winston Salem | Health Care | $2.3 billion |
| 8 | Pitt County Memorial Hospital Inc | Greenville | Health Care | $2.2 billion |
| 9 | Rex Hospital Inc | Raleigh | Health Care | $1.9 billion |
| 10 | Wake Forest University Health Sciences | Winstonsalem | Education | $1.7 billion |
| 11 | Samaritans Purse | Boone | Religion-Related | $1.6 billion |
| 12 | Forsyth Memorial Hospital Inc | Winston Salem | Health Care | $1.6 billion |
| 13 | Duke Health Integrated Practice Inc | Durham | Not listed | $1.3 billion |
| 14 | Research Triangle Institute | Rtp | Science & Technology | $1.3 billion |
| 15 | First Health Of The Carolinas Inc | Pinehurst | Health Care | $1.2 billion |
| 16 | Gothic Hsp Corporation | Durham | Health Care | $974.8 million |
| 17 | Wake Forest University | Winstonsalem | Education | $843.2 million |
| 18 | Atlantic Coast Conference | Charlotte | Recreation & Sports | $826.5 million |
| 19 | Foundation For The Carolinas | Charlotte | Philanthropy, Voluntarism & Grantmaking Foundations | $761.4 million |
| 20 | East Carolina Health | Greenville | Health Care | $599.6 million |
| 21 | The Moses H Cone Memorial Hospital Operating Corporation | Greensboro | Health Care | $598.6 million |
| 22 | Family Health International | Durham | International, Foreign Affairs & National Security | $539.6 million |
| 23 | Sandhills Center For Mental Health Developmental Disabilities & Subst | West End | Mental Health & Crisis Intervention | $532.9 million |
| 24 | High Point Regional Health | High Point | Health Care | $502.9 million |
| 25 | High Point University | High Point | Education | $501.9 million |
The full list includes all 3,077 North Carolina nonprofits with $1M+ revenue, with street address, ZIP, EIN, assets, income and tax period, plus every other state.
North Carolina cities with the most $1M+ nonprofits
- Charlotte: 335
- Raleigh: 305
- Durham: 194
- Greensboro: 137
- Asheville: 133
- Winston Salem: 113
- Wilmington: 87
- Chapel Hill: 73
- Rutherfordton: 51
- Fayetteville: 46
Most common focus areas
- Education: 678
- Human Services: 416
- Health Care: 240
- Public Safety, Disaster Preparedness & Relief: 145
- Arts, Culture & Humanities: 129
- Philanthropy, Voluntarism & Grantmaking Foundations: 118
- Housing & Shelter: 118
- Religion-Related: 101
Where does this data come from?
The IRS Exempt Organizations Business Master File, downloaded in October 2026. Figures are as reported on each organization's latest return on file with the IRS. Personal contact names are not included.